Located in the historic cultural district of Greensburg, Pa., the Seton Hill Performing Arts Center (the PAC) is home to the university's programs of music and theatre. The PAC features two professional-level performance spaces for students, the Reichgut Concert Hall and the Ryan Theatre. The Center also contains classrooms, studios and technical areas designed just for dancers, actors, musicians and costume and set designers to learn and create.

The University's new Arts Center, opened in 2015, features sculpture, graphic design, metalsmithing, clay, photography, printmaking, drawing and painting studios; dance studios and performance spaces; welding facilities and a foundry; and three exhibition spaces - including two galleries and the Art Yard. The Arts Center is located one block down from the University's Performing Arts Center in Greensburg's arts corridor.